Best Bets for NCAA Basketball Picks Against the Spread for Saturday, February 22
Published 9:17 pm Friday, February 21, 2025
The Cal Baptist Lancers versus the Grand Canyon Antelopes is a game to watch on the Saturday college basketball slate that has a lot of compelling matchups. If you’re looking for picks against the spread, our computer model is high on 10 games, including that one.
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Today’s NCAA Men’s Basketball Picks ATS
ATS Pick: Cal Baptist +11.5 vs. Grand Canyon
- Matchup: Cal Baptist Lancers at Grand Canyon Antelopes
- Time: 8 p.m. ET
- Date: February 22
- Computer Projection: Grand Canyon by 5.7 points (Bet now on BetMGM)
- Spread: Grand Canyon (-11.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: Iowa State +12.5 vs. Houston
- Matchup: Iowa State Cyclones at Houston Cougars
- Time: 2 p.m. ET
- Date: February 22
- Computer Projection: Houston by 6.7 points (Bet now on BetMGM)
- Spread: Houston (-12.5)
- TV Channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: Kentucky +11.5 vs. Alabama
- Matchup: Kentucky Wildcats at Alabama Crimson Tide
- Time: 6 p.m. ET
- Date: February 22
- Computer Projection: Alabama by 6 points (Bet now on BetMGM)
- Spread: Alabama (-11.5)
- TV Channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: Florida A&M +7.5 vs. Alabama State
- Matchup: Florida A&M Rattlers at Alabama State Hornets
- Time: 4:30 p.m. ET
- Date: February 22
- Computer Projection: Alabama State by 2.4 points (Bet now on BetMGM)
- Spread: Alabama State (-7.5)
- TV Channel: SWAC Digital Network
ATS Pick: Saint Francis (PA) +1.5 vs. Fairleigh Dickinson
- Matchup: Fairleigh Dickinson Knights at Saint Francis (PA) Red Flash
- Time: 2 p.m. ET
- Date: February 22
- Computer Projection: Saint Francis (PA) by 2.9 points (Bet now on BetMGM)
- Spread: Fairleigh Dickinson (-1.5)
- TV Channel: NEC Front Row
Bet on this or any men’s college basketball matchup at BetMGM.
ATS Pick: Mississippi Valley State +23.5 vs. Texas Southern
- Matchup: Mississippi Valley State Delta Devils at Texas Southern Tigers
- Time: 6 p.m. ET
- Date: February 22
- Computer Projection: Texas Southern by 19.4 points (Bet now on BetMGM)
- Spread: Texas Southern (-23.5)
- TV Channel: SWAC Digital Network
ATS Pick: Campbell +2.5 vs. Towson
- Matchup: Towson Tigers at Campbell Fighting Camels
- Time: 2 p.m. ET
- Date: February 22
- Computer Projection: Campbell by 1.5 points (Bet now on BetMGM)
- Spread: Towson (-2.5)
- TV Channel: FloCollege
ATS Pick: Ole Miss +1.5 vs. Vanderbilt
- Matchup: Ole Miss Rebels at Vanderbilt Commodores
- Time: 3:30 p.m. ET
- Date: February 22
- Computer Projection: Ole Miss by 2.2 points (Bet now on BetMGM)
- Spread: Vanderbilt (-1.5)
- TV Channel: SEC Network
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: American -3.5 vs. Boston University
- Matchup: Boston University Terriers at American Eagles
- Time: 4 p.m. ET
- Date: February 22
- Computer Projection: American by 7.2 points (Bet now on BetMGM)
- Spread: American (-3.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: Delaware State +4.5 vs. South Carolina State
- Matchup: South Carolina State Bulldogs at Delaware State Hornets
- Time: 4 p.m. ET
- Date: February 22
- Computer Projection: South Carolina State by 0.8 points (Bet now on BetMGM)
- Spread: South Carolina State (-4.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
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